Gene Expression Clustering Linked to Glaucoma Protection

by Sheela Philomena on  March 9, 2011 at 11:38 AM Research News
RSS Email Print This Page Comment
Glaucoma, the second most common cause of blindness in the US. In a recent research work, researchers have examined the gene expression patterns in the retina and optic nerve of mice that leads to glaucoma. By clustering these genes researchers were able to identify signature patterns of early events of glaucoma progression. This identification would pave way toward glaucoma protection.
 Gene Expression Clustering Linked to Glaucoma Protection
Gene Expression Clustering Linked to Glaucoma Protection
Advertisement

Activation of part of the innate immune system called the complement cascade, and upregulation of endothelin 2- a protein that can increase blood pressure- were among these early changes. Notably, the researchers found that genetically and pharmacologically interfering with these changes protected mice from developing glaucoma.

Advertisement
The researchers The Jackson Laboratory in Bar Harbor, Maine, Simon John and colleagues believe that they have identified pathways that might be targeted in the development of new glaucoma therapeutics, and hope that their method of clustered gene expression analysis will be useful in uncovering the early molecular events that underlie other diseases.

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

DNA Finger Printing Glaucoma Eye Vision Blindness Facts Eye Redness Eye Pain Symptom Evaluation Ocular Hypertension 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive