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Gene Connected to High Cholesterol in Blood Discovered
Researchers at the Southwest Foundation for Biomedical Research (SFBR) in San Antonio studied a strain of laboratory opossums developed at SFBR that has normal blood levels of "bad" low-density lipoprotein (LDL) cholesterol when fed a standard low-cholesterol diet, but extremely elevated levels of LDL cholesterol when fed a high-cholesterol diet.
These high-responding opossums are used to identify the genes and the underlying mechanisms that control response to dietary cholesterol.
"This research will improve our understanding of cholesterol metabolism and may shed light on why some people have high levels of bad cholesterol in blood while others do not when they consume cholesterol-enriched diets," said John L. VandeBerg, Ph.D., SFBR's chief scientific officer and senior author on the paper.
The study involved analyzing various lipids, or fats, in blood and bile to find differences in cholesterol metabolites, sequencing candidate genes of interest to find mutations, and determining the impact of each mutation by genetic analyses.
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