A20 is a protein, which plays a key role in the generation of the inflammatory response.
VIB researchers led by Geert van Loo and Rudi Beyaert at Ghent University have developed mice with myeloid cells incapable of producing A20.
In collaboration with Dirk Elewaut, rheumatologist at Ghent University Hospital (Ghent University), who co-supervised the research, they found that these mice had elevated levels of pro-inflammatory cytokines in their blood and joints, and spontaneously developed RA with severe inflammation and osteoporosis.
What is arthritis?
The pain in the joints can be effectively eased through the practice of yoga, which gives flexibility to the joints and strength to the muscles of the body parts
The pain in the joints can be effectively eased through the practice of yoga, which gives flexibility to the joints and strength to the muscles of the body parts
The study confirms the crucial role of A20 in the control of inflammatory responses and shows that a defect in A20 in myeloid cells can give rise to RA that is not responsive to anti-TNF treatment.
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New Study Says Use of Placebo in Rheumatoid Arthritis Clinical Trials may Negatively Impact Patients
The debate on whether it is ethical to conduct placebo-controlled studies where patients in the placebo-group are at a serious disadvantage has been re-opened
The debate on whether it is ethical to conduct placebo-controlled studies where patients in the placebo-group are at a serious disadvantage has been re-opened
The study has been published in Nature Genetics.
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Rheumatoid Arthritis Patients Don't Receive Statins After Heart Attack
Around 20% of rheumatoid arthritis patients are not receiving the recommended therapies, such as statins and betablockers, following a first heart attack.
Around 20% of rheumatoid arthritis patients are not receiving the recommended therapies, such as statins and betablockers, following a first heart attack.
