Scientists have revealed that hormonal messages that help to reduce the production of lethal toxins by pathogenic bacteria, could be a better way to treat serious food-borne infections.
Vanessa Sperandio said that gut bacteria, including harmful strains of Escherichia coli and Salmonella that cause food poisoning, detect and respond to adrenaline released by the host, through a sensor called QseC embedded in the bacterial surface.
AdvertisementWhen adrenaline binds to QseC, it is like toppling the first tile of a complex domino arrangement - it triggers a chain of events that can ultimately result in the production of toxins.
Sperandio's group at the University of Texas Southwestern Medical Center have identified a molecule, called LED209, which stops adrenaline binding to QseC.
Blocking binding prevents the signalling events inside the bacterium, reducing toxin production and also hindering bacteria from attaching effectively to the epithelial cells that line the gut.
When given orally to infected mice, LED209 could reduce the number of gut-colonising Salmonella.
The discovery could represent the first of a novel class of antimicrobial agents.
"QseC is a very attractive drug target because it is present in at least 25 important animal and plant pathogens but not in mammals.This means that drugs targeting this sensor are less likely to be toxic and have the potential to be broad-spectrum (effective against several types of infection)," said Sperandio.
She added that alternative treatments are needed for pathogenic E. coli and Salmonella infections, as antibiotic treatment can make the illness worse.
"Conventional antibiotics can trigger the SOS response in bacteria that actually enhances virulence. LED209, unlike antibiotics, does not kill or hinder E. coli growth and onsequently does not promote expression of shiga toxin - which is the bacterium's defence mechanism. Instead, LED209 decreases expression of genes that encode this toxin," she said.
"What is more, because this signalling system does not directly influence bacterial growth, inhibiting it may not exert a strong selective pressure for the development of resistance," she added.
The findings were presented at the Society for General Microbiology's spring meeting in Edinburgh.
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