Food Additive Used In Processed Food Might Increase Lung Cancer Risk

by priya on  December 31, 2008 at 11:48 AM Cancer News
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Increased dietary intake of inorganic phosphate, a common food additive found in various processed food, is suspected to increase the risk and spread of lung cancer. The results were evident with a study conducted on mouse model.

Conducted by Myung-Haing Cho, D.V.M., Ph.D., and his colleagues at Seoul National University, the study also suggested that dietary regulation of inorganic phosphates might play an important role in lung cancer treatment.

"Our study indicates that increased intake of inorganic phosphates strongly stimulates lung cancer development in mice, and suggests that dietary regulation of inorganic phosphates may be critical for lung cancer treatment as well as prevention," said Cho.

The study revealed that high levels of inorganic phosphates can stimulate non-small cell lung cancer (NSCLC) pathways.

"Lung cancer is a disease of uncontrolled cell proliferation in lung tissue, and disruption of signaling pathways in those tissues can confer a normal cell with malignant properties. Deregulation of only a small set of pathways can confer a normal cell with malignant properties, and these pathways are regulated in response to nutrient availability and, consequently, cell proliferation and growth," explained Cho.

He added: "Phosphate is an essential nutrient to living organisms, and can activate some signals. This study demonstrates that high intake of inorganic phosphates may strongly stimulate lung cancer development by altering those (signaling) pathways."

For the study, the researcher analysed lung cancer-model mice for four weeks.

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