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Fiber in Diet Reduces Plant Cholesterol Absorption When Taken With Cholesterol Lowering Tablets
Ezetimibe is a comparatively newer drug that acts by decreasing absorption of cholesterol and phytosterols by the intestines. It is usually used along with statins for added beneficial effect.
Phytosterols are similar to cholesterol but obtained from plant sources like nuts and legumes.
Studies indicate that souble fibre in the intestines reduce the absorption of Phytosterols from the diet and thus have a cholesterol-lowering effect. Other studies however indicate that increase in absorption of phytosterols could have the same detrimental effects on the body as cholesterol such as hardening of blood vessels.
Some studies indicate that the cholesterol-lowering drugs belonging to the statin group, though very effective, can increase the absorption of phytosterols in the intestine, leading to a mild to moderate increase of phytosterols in the body. This could lead to an increase in cardiovascular risk, though this view is still controversial.
Dietary fibers have been shown to reduce blood cholesterol in prior studies. They could be used along with cholesterol lowering drugs- thus they may enhance the effect of the drugs as well as allow the use of lower doses of the cholesterol-lowering drugs, thereby reducing their side effects.
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