Children whose fathers smoked around the time of their conception have at least a 15% higher risk of developing the most common form of childhood cancer, acute lymphoblastic leukemia (ALL), according to researchers at Telethon Institute for Child Health Research, Australia.
Researchers surveyed the families of nearly 300 children with ALL, inquiring about the smoking habits of both parents. They compared these findings with those of families of more than 800 children of similar ages who did not have leukemia.
AdvertisementThey found that the mothers smoking behavior had no impact on the children's risk of developing the cancer, but children whose fathers smoked at the time of their conception were 15% more likely to develop leukemia. Kids whose fathers smoked at least 20 cigarettes per day were 44% more likely to be diagnosed with the disease.
Lead author of the study Elizabeth Milne said, "Study results suggest that heavier paternal smoking around the time of conception is a risk factor for childhood ALL. Tobacco is full of toxins, including carcinogens, it was not unlikely that there could be damage in the cells that produce sperm. Sperm containing DNA (damage) can still reach and fertilize an ovum, which may lead to disease in the offspring. However, the study did not prove that DNA damage in the sperm caused ALL in the children, since the disease was likely to be caused by a number of factors. The study is published in the American Journal of Epidemiology.
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