login
Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Fatal Fever Caused by Waste By-product of Malaria Parasite's Reproductive Process
Lead researcher Dr. Martin Olivier, of McGill University in Montreal, points out that, inside the human body, the malaria parasite infects red blood cells where it survives and reproduces by feeding on the cells' contents.
Eventually, says the researcher, the cells burst and release the parasites and hemozoin.
"Our results describe the mechanism by which the hemozoin activates the immune system, resulting in the production of inflammation mediators and in the high fever that we witness in malaria patients," said study's first-author Dr. Marina Tiemi Shio, of the Research Institute of the McGill University Health Centre (RI-MUHC).
According to the researchers, hemozoin is first ingested by "cleaning" cells called macrophages, which leads to a chain reaction ending in the activation of the inflammasome: an important structure inside immune cells which lead to inflammation.
They say that the activation of the inflammasome leads to the production of the body's fever mediator, interleukin beta (IL-beta).
"Our work is a milestone in that it is the first study that reveals the enzymes that act as intermediary between the hemozoin and inflammasome. Now our picture of the process that goes from infection to fever is more or less complete," said Dr. Olivier.
|
|
|
More News on: Malaria-water, Malaria, Mosquito Diseases, Febrile Fits / Febrile Convulsions , Q Fever, Fever
 Comment & Contribute
|
Medwonders Health Network
- Health News Index
 | Quiz on Malaria Malaria is a common parasitic disease of the tropics, resulting in million deaths every year. Early detection and adequate treatment at the right time can reduce deaths due to malaria. Test your knowledge on this condition by taking this quiz. 
|
- News Quick Links
 |
Fever
Complete Medindia Resources
|
| News Categories: |
| » | Post Surgery Will the Tumour Return? New Breast Cancer Test to Predict Exactly |
| » | Scientists Develop Compound That Triggers Cancer Cell Death |
| » | Iraqi National Hopes to Find Affordable Treatment for His Cancer in India |
| » | New Technique can Help Doctors Detect Pancreatic Cancer |
| » | Colorectal Cancer Risk Factors Probed |
| More Cancer News | |
|
