Fatal Brain Infections can be Resolved by Singapore Nanotechnology

by Rajashri on  June 29, 2009 at 8:37 PM Research News
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A novel peptide nanoparticles developed by scientists at the Institute of Bioengineering and Nanotechnology (IBN) of Singapore could help doctors treat meningitis treatment and go to war on drug-resistant bacteria and fungal infections. The details are reported in Nature Nanotechnology.

The stable bioengineered nanoparticles devised at IBN effectively seek out and destroy bacteria and fungal cells that could cause fatal infections and are highly therapeutic.

Major brain infections such as meningitis and encephalitis are a leading cause of death, hearing loss, learning disability and brain damage in patients.

IBN's peptide nanoparticles, on the other hand, contain a membrane-penetrating component that enables them to pass through the blood brain barrier to the infected areas of the brain that require treatment. The ability of IBN's peptide nanoparticles to traverse the blood brain barrier offers a superior alternative to existing treatments for brain infections. The brain membrane is impenetrable to most conventional antibiotics because the molecular structure of most drugs is too big to enter the membrane.

"Our treatment damages the structure of the pathogen and literally breaks it apart," said Yiyan Yang, Ph.D., group leader at IBN, one of the research institutes sponsored by Singapore's A*STAR (Agency for Science, Technology and Research).

"Our oligopeptide has a unique chemical structure that forms nanoparticles with membranepenetrating components on their surface," Dr. Yang added. "These nanoparticles can easily enter bacteria, yeast or fungal cells and destabilize them to cause cell death. For example, the nanoparticles cause damage to bacteria cell walls and prevent further bacterial growth."

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