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Faster and Cheaper Approach for Human Genome Analysis on the Anvil
The researchers used bar-codes to catalogue portions of the nearly three-billion-base human genetic code, which may help scientists to specifically locate the regions most likely to show variations in genetic traits.
According to Dr. David Craig, associate director of TGen's Neurogenomics Division, the new method will only cost one-tenth of the current cost of gene sequencing,
Gene sequencing is usually done to analyze Single Nucleotide Polymorphisms (SNPs), and in performing Genome-Wide Association (GWA) studies.
"Our goal is to find the genetic basis of disease. It (the new method) provides us a way to immediately use next-generation sequencing technology for studying hundreds to thousands of individuals,'' Nature magazine quoted Craig, the study's lead author, as saying.
John Pearson, the head of TGen's Bioinformatics Research Unit, claimed that with the new method, scientists worldwide would find it easier to tune their sequencing experiments, and also conduct their experiments with greater speed.
"In many cases, rather than sequencing the whole genome for 10 people, researchers would rather sequence a dozen genes for 1,000 people,'' said Pearson, who contributed to the study.
For their study, the researchers resorted to an exciting new technology called "next generation sequencing'' to allow samples to be run and analysed using 15 well-characterized indexes.
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