Facial reconstruction patients may soon be able to avail custom-made bone replacements optimized for both form and function, reveal researchers at the University of Illinois.
Whether resulting from illness or injury, loss of facial bones poses problems for reconstructive surgeons beyond cosmetic implications-the patient's chewing, swallowing, speaking or even breathing abilities may be impaired.
Advertisement"The mid-face is perhaps the most complicated part of the human skeleton. What makes mid-face reconstruction more complicated is its unusual unique shape (bones are small and delicate) and functions, and its location in an area susceptible to high contamination with bacteria," said Glaucio Paulino, the Donald Biggar Willett Professor of Engineering at U. of I.
To fashion bone replacements, surgeons often will harvest bone from elsewhere in the patient's body - the shoulder blade or hip, for example - and manually fashion it into something resembling the missing skull portion.
However, since other bones are very different from facial bones in structure, patients may still suffer impaired function or cosmetic distortion.
The interdisciplinary research team applied an engineering design technique called topology optimization.
The approach uses extensive 3-D modeling to design structures that need to support specific loads in a confined space, and is often used to engineer high-rise buildings, car parts and other structures.
"It tells you where to put material and where to create holes. Essentially, the technique allows engineers to find the best solution that satisfies design requirements and constraints," said Paulino.
Paulino said that facial reconstruction seemed a natural fit for the technique.
"We looked at the clinical problem from a different perspective. Topology optimization offers an interdisciplinary framework to integrate concepts from medicine, biology, numerical methods, mechanics, and computations," he added.
Topology optimization would create patient-specific, case-by-case designs for tissue-engineered bone replacements.
First, the researchers construct a detailed 3-D computer model of the patient in question and specify a design domain based on the injury and missing bone parts.
Then a series of algorithms creates a customized, optimized structure, accounting for variables including blood flow, sinus cavities, chewing forces and soft tissue support, among other considerations.
The researchers can then model the process of inserting the replacement bone into the patient and how the patient would look.
"Ideally, it would allow the physician to explore surgical alternatives and to design patient-specific bone replacement. Each patient's bone replacement designs are tailored for their missing volume and functional requirements," said Paulino.
"This technique has the potential to pave the way toward development of tissue engineering methods to create custom fabricated living bone replacements in optimum shapes and amounts. The possibilities are immense and we feel that we are just in the beginning of the process," said Paulino.
The study results are published in the latest edition of the Proceedings of the National Academy of Sciences.
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