The brains of people with Alzheimer's disease are less well connected than the brains of people without the disorder, says a new research, which was based on concepts borrowed from Facebook.
The test, which relies on common brain-imaging techniques, may be the first step toward a new diagnostic tool to differentiate early-stage Alzheimer's disease from other disorders, according to Stanford University School of Medicine researchers.
"People can struggle with memory loss as a part of healthy aging, or as a result of depression or non-Alzheimer's dementia. It's important to be able to tell the difference," said Michael Greicius, MD, assistant professor of neurology.
The symptoms of Alzheimer's disease include memory loss and changes in thinking and behavior.
Although there is no cure for the disorder, an early diagnosis can help patients and their family members prepare for the future and treat symptoms as they arise. However, the mild indicators of early-stage disease can be difficult to diagnose correctly.
In the research, the scientists used a technique called functional magnetic resonance imaging, or fMRI, which examines patterns of oxygen use in the brain to analyze brain activity.
Unlike many studies, in which patients are asked to visualize certain events, listen to music or perform certain mental tasks during fMRI, Greicius, along with Vinod Menon, PhD, and other colleagues simply analyzed the normal, ongoing chatter that occurs in a resting brain. That made the test easier for patients with mild dementia to take and researchers to analyze.