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Exposure to Second-Hand Tobacco Smoke Linked to Liver Disease
Scientists at the University of California, Riverside (UCR) have found that exposure to second-hand tobacco smoke can lead to non-alcoholic fatty liver disease (NAFLD), a common disease and rising cause of chronic liver injury wherein fat accumulates in the liver of people who drink little or no alcohol.
For their study, the researchers exposed some mice to second-hand cigarette smoke for a year in the lab, and observed fat build-up in their liver cells, a sign of NAFLD that eventually leads to liver dysfunction.
The researchers focused on two key regulators of lipid (fat) metabolism that are found in many human cells as well: SREBP (sterol regulatory element-binding protein) that stimulates synthesis of fatty acids in the liver, and AMPK (adenosine monophosphate kinase) that turns SREBP on and off.
They found that second-hand smoke exposure inhibits AMPK activity, which, in turn, causes an increase in activity of SREBP.
More active SREBP results in more fatty acids getting synthesized, they say.
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More News on: Alcoholic Liver Disease, Liver Biopsy, Health Hazards of Smoking, Hepatitis A, Smoking And Cancer, Smoking And Tobacco, Smoking Risk, Diet Lifestyle and Heart Disease, Liver, Wilson's Disease
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