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Experts Recommend Universal Screening of Newborns for Congenital Adrenal Hyperplasia
- Prenatal treatment of CAH should continue to be regarded as experimental. Such therapies should be pursued through protocols approved by Institutional Review Boards at centers capable of collecting outcomes data on a large number of patients so that risks and benefits of this treatment can be defined more precisely;
- Diagnosis should rest on clinical and hormone data while genotyping should be reserved for equivocal cases and genetic counseling;
- Regarding treatment, glucocorticoid dosage should be minimized to avoid iatrogenic Cushing's Syndrome. Mineralcorticoids and, in infants, supplemental sodium are recommended in classic CAH patients;
- Clinicians should avoid the routine use of experimental therapies to promote growth and delay puberty, and patients should avoid adrenalectomy;
- Early single-stage genital repair should be considered for severely virilized girls and should be performed only by surgeons experienced in this type of procedure;
- Clinicians should consider patients' quality of life, consulting mental health professionals as appropriate;
- At the transition to adulthood, clinicians should monitor for potential complications of CAH; and
- Clinicians should exercise judicious use of medication during pregnancy and in symptomatic patients with nonclassic CAH.
"People with classic CAH should have a team of health care providers, including specialists in pediatric endocrinology, pediatric urologic surgery (for girls), psychology and genetics," said Speiser. "Other than having to take daily medication, people with classic CAH can have a normal life."
Source-Eurekalert
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