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Exercise Can Undo Damage in Heart Failure Patients
Regular endurance exercise promotes the growth of new cells and blood vessels in muscles that may have become weak and shrunken due to a failing heart's inability to pump enough blood to the body's organs, German researchers told a meeting of the American Heart Association in Orlando, Florida.
"If you have heart failure, exercise training can improve your health status, increase your ability to exercise and reverse patterns of muscle damage that are common in heart failure," said Axel Linke, assistant professor of medicine at the University of Leipzig, Germany and a co-author of both studies.
One of the studies showed that daily exercise sharply increased the level of progenitor cells in the muscle tissue of men who engaged in daily workouts.
Progenitor cells make up a pool of immature cells found in skeletal muscle that can divide into various mature cells as needed for muscle repair. People with heart failure typically have 50 percent fewer of these cells than healthy people.
Biopsies of the quadricep muscle in the thigh showed that men with moderate to severe heart failure who did 30 minutes exercise a day on a stationary bike, at about half their peak exercise capacity, had a 100 percent increase in levels of progenitor cells over a six month period.
"With exercise, the number of progenitor cells became almost normal, the cells started to divide again and they began to differentiate into myocytes (muscle cells). And that's exactly what patients with heart failure need - replacement of muscle cells," Linke said.
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