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Evolution of Human Allergies Highlighted by Ancient Antibody Molecule
"We know that part of the problem with IgE in humans is that it binds extremely tightly to white blood cells causing an over-reaction of the immune system and so we wanted to find out whether IgY does the same thing."
By examining how tightly IgY binds to white blood cells the researchers have found that it behaves in a much more similar way to the human IgG, which is not involved in allergic reactions and binds much less tightly.
Professor Brian Sutton, head of the laboratory where the work was done said: "It might be that there was a nasty bug or parasite around at the time that meant that humans needed a really dramatic immune response and so there was pressure to evolve a tight binding antibody like IgE."
"The problem is that now we've ended up with an antibody that can tend to be a little over enthusiastic and causes us problems with apparently innocuous substances like pollen and peanuts, which can cause life-threatening allergic conditions."
The next stage of the work is to examine in very fine detail the interaction between the antibodies and the surface of the white blood cell.
This is with a view to designing drugs that could alter this interaction and therefore 'loosen' the binding of IgE, making it more like its chicken counterpart.
The study appears in The Journal of Biological Chemistry.
Source-ANI
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More News on: Choose The Right Over-the-Counter Drugs for Allergy
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Aveslab(Guest)
11/06/2009
Aves Labs specializes in Custom Chicken Antibody (IgY) production, development and purification. Design and order your antibodies online, easily and securely.
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kyraangel666(Guest)
02/19/2009
guest
06/15/2008
By studying this molecule, we can track the evolution of allergic reactions back to at least 160 million years ago... Not. The earth is only 6000 years of age. The Quest for Right, a new 7-book series on origins based on physical science, traces the dynasty of Jesus back to the first day of creation: September 13, 2007 BC. This is in accordance with history as recorded on instrumentation, not conjured up in the vain imiginations of evolutionists. |
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