The mice that drank alcohol had twice as many dark-furred offspring compared to mothers who were not exposed to alcohol. The resulting change in coat colour is an indication of the changed epigenetic state of the coat colour gene.
Some alcohol-exposed offspring exhibited subtle skull malformations, similar to features seen in human fetal alcohol syndrome (FAS) - a condition that causes growth restriction, intellectual disabilities and changes to the shape and size of the skull as a result of high levels of alcohol consumption during pregnancy.
FAS has devastating long-term consequences for the individuals themselves and their families and the number of reported cases in Australia is increasing.
Dr Chong is hopeful her team's research will further our understanding of fetal alcohol spectrum disorders and in the future these epigenetic changes may be used to aid diagnosis of this condition, allowing for early intervention.
The paper was published in
PLoS Genetics on 15 January.
Source-Medindia
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