For family members without this genetic lung cancer risk, the risk of developing the disease tracked closely with the level of smoking-in other words, heavy smokers had a significantly greater risk of developing lung cancer than moderate smokers, who had a significantly greater risk than light smokers.
But in family members with the genetic risk haplotype, even light smoking resulted in a greatly increased risk for developing lung cancer. From there, increasing smoking behaviours in this group of family members carried only weakly increasing risk for developing lung cancer.
Susan Pinney, a co-author of the study, said: "If you carried the inherited risk and then you smoked, it didn't matter if you were a light smoker or a heavy smoker-you were significantly more likely to develop lung cancer."
The study has been published online March 9, 2010, ahead of print by Cancer Research.
Source-ANI
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