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Erectile Dysfunction Drug may Help to Treat Rheumatic Diseases
Researchers at Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) in Lucknow say that an erectile dysfunction treatment may also be effective in treating blood vessel narrowing in rheumatic diseases.
Dr. Padmanabha Shenoy, from the department of immunology, says that when used in addition to other treatments, tadalafil is effective and well tolerated in the treatment of secondary Raynaud's phenomenon, in which blood vessels narrow abnormally when exposed to cold and blood supply to the hands and feet decreases as a result.
During the study, the research team studied the effectiveness and tolerability of tadalafil as an additional therapy to treat patients with secondary Raynaud's phenomenon, who had not successfully responded to treatment with vasodilators-a common treatment that relaxes the smooth muscles in blood vessels.
Twenty-five patients, mostly females with an average age of 37, were randomly selected to receive either tadalafil or placebo for six weeks as an add-on treatment to their usual vasodilator therapy.
After the initial six weeks, patients received a seven-day break, and then those initially administered tadalafil began taking placebo, and vice versa.
The researchers recorded the frequency and duration of Raynaud's episodes.
They also watched for the healing of existing and the appearance of new fingertip ulcers, and performed physician and patient assessments of the overall severity of Raynaud's phenomenon.
Twenty-four of the 25 patients completed the study.
Dr. Padmanabha Shenoy, from the department of immunology, says that when used in addition to other treatments, tadalafil is effective and well tolerated in the treatment of secondary Raynaud's phenomenon, in which blood vessels narrow abnormally when exposed to cold and blood supply to the hands and feet decreases as a result.
During the study, the research team studied the effectiveness and tolerability of tadalafil as an additional therapy to treat patients with secondary Raynaud's phenomenon, who had not successfully responded to treatment with vasodilators-a common treatment that relaxes the smooth muscles in blood vessels.
Twenty-five patients, mostly females with an average age of 37, were randomly selected to receive either tadalafil or placebo for six weeks as an add-on treatment to their usual vasodilator therapy.
After the initial six weeks, patients received a seven-day break, and then those initially administered tadalafil began taking placebo, and vice versa.
The researchers recorded the frequency and duration of Raynaud's episodes.
They also watched for the healing of existing and the appearance of new fingertip ulcers, and performed physician and patient assessments of the overall severity of Raynaud's phenomenon.
Twenty-four of the 25 patients completed the study.
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