Erectile Dysfunction Drug Can Help Treat Congenital Heart Disease

by VR Sreeraman on  March 12, 2011 at 1:12 PM Drug News
RSS Email Print This Page Comment bookmark
Font : A-A+

A drug used to treat erectile dysfunction and pulmonary hypertension, has another possible use-helping children and young adults with congenital heart disease to better tolerate exercise, scientists have found.
 Erectile Dysfunction Drug Can Help  Treat Congenital Heart Disease
Erectile Dysfunction Drug Can Help Treat Congenital Heart Disease

Researchers from The Children's Hospital of Philadelphia show the drug, called Sildenafil, significantly improved measures of exercise performance during stress testing in patients with single-ventricle heart disease,

All patients involved in the study had earlier undergone the Fontan operation, a procedure that redirects systemic venous blood directly to the pulmonary arteries, bypassing the heart.

It is the third operation in a staged series of surgeries for single-ventricle heart defects, life-threatening conditions in which a child is born with severe underdevelopment of one of the pumping chambers of the heart.

"Despite dramatically improved early operative success achieved over the past 20 years, morbidity and mortality are still a challenge for children who have undergone a Fontan operation," said David J. Goldberg, primary investigator of this study.

"The staged palliation does not recreate a normal two-ventricle circulation; instead the series of surgeries creates a unique physiology in which exercise capacity is dramatically diminished," he said.

In this study, researchers randomized 28 children and young adults who had undergone the Fontan operation an average of 11 years earlier to receive either placebo or sildenafil three times a day for 6 weeks.

The researchers found significant improvements in exercise performance during treatment with sildenafil compared to placebo.

The findings included improved ventilatory efficiency and, in two subgroups of patients, an improved ability to perform moderate levels of exercise. These changes suggest an overall improvement in the physiology associated with this unique circulation.

This study was published online on March 7 in the journal Circulation.

Source: ANI

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Correct me if I'm wrong. I think Sildenafil is the generic name for Viagra. Wow, this drug certainly has a lot of potential.

Related Links

More News on:

Drugs In Impotence Drug Toxicity Erectile Dysfunction Priapism Cardiac Catheterization Heart Attack Air travel: To fly or not to fly Diet Lifestyle and Heart Disease Patent Ductus Arteriosus Congenital Heart Disease 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive