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Enzymes as Anticancer Therapeutic Agents
The novel enzyme create new agents to treat cancer and fight infection and is capable of changing the chemical properties of a variety of existing drugs and small molecules said Researchers at the University of Wisconsin-Madison School of Pharmacy.
"We're finding this enzyme glycosylates all sorts of molecules," Nature magazine quoted Jon Thorson, professor of pharmaceutical sciences, as saying while describing the process of adding natural sugar molecules to other chemical molecules to enhance their biological effects.
Thorson likens the newly evolved enzyme, which he developed working with colleagues Gavin J. Williams and Changsheng Zhang, to a Swiss Army enzyme, a catalyst that can decorate many different chemical molecules with all sorts of sugars to alter their biological effects.
Enzymes are proteins that act as catalysts across biology, from single-celled organisms to humans. They are also important for making so-called natural drugs, therapeutic agents based on the blueprints of chemicals produced in nature by plants and microorganisms.
Such natural sugar-bearing chemicals are the basis for some of medicine's most potent antibiotics and anticancer drugs, as exemplified by the antibiotic erythromycin and the anticancer drug doxorubicin.
Although scientists can sometimes manipulate how sugars are added or subtracted to a chemical molecule to alter its therapeutic properties, it is difficult and not always possible to routinely modify them to enhance their beneficial effects.
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