Enzyme That Plays Key in Aging Identified

by VR Sreeraman on  July 12, 2009 at 1:35 PM Anti-Aging News
RSS Email Print This Page Comment
 Enzyme That Plays Key in Aging Identified
Scientists from University of Pittsburgh School of Medicine have identified an enzyme that plays a crucial role in the process of aging.
Advertisement

Lead researcher Dr. Abbe de Vallejo, associate professor of Pediatrics and Immunology, has found that eliminating pregnancy-associated plasma protein A (PAPPA) enzyme increases the lifespan of study mice.

Advertisement
The researcher revealed that PAPPA enzyme has the ability to promote a robust immune system into old age, by maintaining the function of the thymus throughout life.

Thymus is the organ that produces T cells to fight disease and infection. It degenerates with age.

The study showed that PAPPA-knockout mice live at least 30 percent longer, and have significantly lower occurrence of spontaneous tumors than typical mice.

PAPPA controls the availability in tissues of a hormone known as insulin-like growth factor (IGF) that is a promoter of cell division. Hence, IGF is required for normal embryonic and postnatal growth.

IGF is associated with tumor growth, inflammation, and cardiovascular disease in adults.

By deleting PAPPA, the researchers were able to control the availability of IGF in tissues and dampen its many ill effects.

In the thymus, deletion of PAPPA maintained just enough IGF to sustain production of T cells without consuming precursor cells, thereby preventing the degeneration of the thymus.

"Controlling the availability of IGF in the thymus by targeted manipulation of PAPPA could be a way to maintain immune protection throughout life," de Vallejo said.

"This study has profound implications for the future study of healthy aging and longevity," de Vallejo added.

The study has been published in the Proceedings of the National Academy of Sciences.

Source: ANI
SRM
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Ageing and Sleep Food Preservatives - How Safe Are They? Telomere Shortening And Ageing 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive