login
Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Emotional Stress Could Be a Factor in Causing Alzheimer’s: Study
When the researchers restrained mice for half an hour, it resulted only in a transient phosphorylation of tau. But when they simulated chronic stress by repeating the procedure every day for two weeks, the modification lasted long enough to let tau molecules tumble off the cytoskeleton and pile up in insoluble heaps of protein.
During the study, the researchers genetically engineered mice to lack either CRFR1 or CRFR2.
“And sure enough, the CRF receptors turn out to be integrally and differentially involved,” says Sawchenko.
In the absence of CRFR1, stress-induced tau phosphorylation was abrogated, while in mice missing CRFR2 the effect was amplified, says the researcher, adding that pharmacological studies with small molecule inhibitors replicated the effect.
“We may have discovered another application. Such drugs could have a prophylactic effect or delay the progression of Alzheimer’s disease,” Sawchenko says.
Source-ANI
SRM/M
|
|
|
More News on: Life Stressors, Palpitations And Arrhythmias, Life Stress, Stress Relief Through Alternative Medicine, Stress and the Gender Divide, Andropause / Male Menopause, Headache / Cephalgia, Heart Attack- Lifestyle Risks, Is Your Man Moody?, Tired All The Time
 Comment & Contribute
|
Medwonders Health Network
- Health News Index
- News Quick Links
| News Categories: |
| » | Revision in Quality Standards for Heparin |
| » | Acne Drug Users At High Risk of Developing Eye Infections |
| » | Patients Who Take Antidepressants When in ICU More Likely to Die |
| » | New Tablet Coating Product by Ideal Cures, In Geneva |
| » | Prednisolone Benefits Patients With Bell's Palsy |
| More Drug News | |
|
