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Embryonic Stem Cell Therapy Closer to Human Trials

by Sreeraman on November 21, 2009 at 12:33 PM Genetics & Stem Cells News

Embryonic stem cell therapy got a step closer to the clinic after US researchers said they filed a request for government approval of human trials.

Embryonic Stem Cell Therapy Closer to Human Trials

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The trials would involve 12 patients losing their sight to a currently untreatable disease called Stargardt, which is one of the most common forms of juvenile blindness.

The treatment would consist of a single injection of retinal cells derived from embryonic stem cells.

Previous studies in rats and mice have found that the treatment prevented further vision loss without adverse side effects, said Robert Lanza, the chief scientific officer at Advanced Cell Technology.

It works by replacing lost retinal cells, called retinal pigment epithelium (RPE), which maintain the photoreceptors needed for vision.

"If you start to lose these RPE, the environment for the photoreceptors degenerates," Lanza said in a telephone interview.

"By putting these RPEs back in you can prevent the loss of these photoreceptors and prevent blindness."

The trials could begin as early as the beginning of next year if the Food and Drug Administration grants approval, Lanza said.

This is just the second proposal for a clinical trial of embryonic stem cell therapies that has been submitted for approval, he added.

The other project, which would address spinal cord injuries, has been placed on hold and is not expected to begin before the third quarter of 2010, according to a recent press release from California-based Geron.

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