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Effectiveness of Fibrate Drugs in Diabetes Patients

by Sheela Philomena on  August 12, 2011 at 10:12 AM Drug News   - G J E 4
Fibrate drugs have not been successful at preventing heart attack in type 2 diabetes patients with elevated cholesterol, says a commentary in the current New England Journal of Medicine.
 Effectiveness of Fibrate Drugs in Diabetes Patients
Effectiveness of Fibrate Drugs in Diabetes Patients
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The drugs, called fibrates, seek to lower blood triglyceride levels and raise the amount of HDL cholesterol. They often are prescribed to diabetes patients as an add-on to statins, drugs that lower LDL cholesterol. Annual sales in the U.S. for the three fibrates now approved by the FDA — gemfibrozil (Lopid), fenofibrate (Tricor) and fenofibric acid (Trilipix) — amount to billions of dollars.

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"There have been few studies regarding the clinical outcome efficacy of fibrates," said Sanjay Kaul, MD, a commentary author and director of the Cardiology Fellowship Training Program at the Cedars-Sinai Heart Institute. "Thousands and thousands of Americans take fibrates every day but so far, there are no long-term studies showing that fibrates lower cardiovascular risk or improve survival among diabetes patients who are also on statins."

The commentary calls for more studies. Meantime, the authors suggest that doctors prescribe the statin-fibrate combination only to diabetic patients at high risk for a heart attack and only after optimal control of LDL cholesterol has been achieved with statin treatment.

Source: Eurekalert
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