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Effectiveness and Safety of New Treatment for Hemophilia Confirmed in Tulane-Led Study
The study, the first to confirm the efficacy and safety of the drug FEIBAâĒ in bleed prevention is published in the November 3, 2011 issue of The New England Journal of Medicine.
The study examined the ability of FEIBA to prevent bleeds in people with severe hemophilia A with inhibitors. People with this condition produce antibodies known as inhibitors. These inhibitors render ineffective the usual treatment for hemophilia, which involves replacement of the blood clotting factor (Factor VIII) that is absent in hemophilia patients. Approximately 30 percent of patients with severe hemophilia A develop such "inhibitor" antibodies. Hemophilia A patients with inhibitors require treatments with alternate forms of clotting factor concentrates, known as bypassing agents, and until recently primarily had to be infused with clotting factors "on demand" as bleeding episodes occur. Treatment of bleeding events in these patients is not always effective, leading to significant problems for patients, who typically experience repeated joint bleeding and progressive joint disease.
The Tulane-led study tested if preventive treatment with the bypassing agent FEIBA is safe and effective in preventing joint and other bleeds in hemophilia A patients with inhibitors. Thirty-four patients were enrolled for the 15-month-long study.
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