In EBS patients, skin blisters heal without scarring, correlating with an induction in the expression of the protein K6, to which K5 is related, and of K17 and K16, to which K14 is related. In transgenic mouse models, these keratins are indeed partially redundant in their ability to provide structural support in skin keratinocytes.
When mice with EBS with a K14 deficiency were exposed to sulforaphane, the researchers noted that it significantly reduced epidermal blistering while it was ineffective for a K5 deficient mouse. Sulforaphane still has a long way to go before it can be tested clinically with EBS patients, but the researchers noted that extracts from broccoli sprouts rich in sulforaphane have already been shown to be safe for use in human skin.
The study was reported at the American Society for Cell Biology 47th Annual Meeting.
Source-ANI
KAR/P