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Drug-eluting Stents Without Polymers may Help Treat Blocked Coronary Arteries
April 05, 2008 at 2:20 PM
Heart Disease News
The breakthrough reported by MIV Therapeutics Inc., a company based at Atlanta in Georgia, attains significance because it shows a possibility of doing away with stents made of materials that are believed to be a cause of restenosis, re-blocking of arteries, after the treatment.
The Brazilian study was conducted by Dr. Alexandre Abizaid at Institute Dante Pazzanese of Cardiology in Sao Paolo, during which the researchers implanted stents in fifteen patients.
The team measured the extent of restenosis at four and nine months using two independent measures-an imaging technique called intravascular ultrasound and quantitative coronary angiography, which uses a radioactive tracer injected into the heart to detect blockages through an X-ray camera positioned outside the body.
The first four months were allowed for healing, while the subsequent time point was chosen for inflammatory or cell-proliferative responses.
The researchers used the ultrasound to measure "volumetric obstruction" that relates to the percentage of the stent volume that has filled, and the angiography to measure "late-lumen loss" that signifies the reduction of the free path through the stent area at its narrowest.
There was not statistically significant narrowing of blood vessels inside the VESTASync stent at nine months, compared to the results of the patients at four months.
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