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Drug That Lowers Blood Pressure may Prevent Pancreatic Cancer Spread
April 15, 2008 at 6:54 PM
Drug News
In previous studies, Hwyda Arafat, M.D., Ph.D., associate professor of Surgery at Jefferson Medical College, and her colleagues showed that angiotensin receptor blockers might help reduce the development of tumour-feeding blood vessels, a process called angiogenesis.
Other studies have associated a lower incidence of cancer with the use of angiotensin blocking therapies. Arafat said that theses drugs might become part of a novel strategy to control the growth and spread of cancer.
One such drug, AT1R (Ang II type 1 receptor) blockers, inhibits the function of the hormone angiotensin II (Ang II) in the pancreas.
The receptor is expressed in pancreatic cancer cells. Ang II boosts the production of VEGF, a vascular factor that promotes blood vessel growth in a number of cancers.
High levels of VEGF have been linked to poor cancer prognosis and early recurrence after surgery. Dr. Arafat and her team have shown that AngII indirectly causes VEGF expression by boosting AT1R expression.
Researchers investigated the effects of blocking AT1R on the pancreatic cancer cell reproductive cycle and programmed cell death, or apoptosis, and the mechanisms involved.
They found that blocking AT1R inhibited pancreatic cancer cell growth and promoted cell death.
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