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Drug That Enhance Re-growth and Healing of Injured Bones Found
Researchers injected DF into injured mouse bones. They found that the drug triggered the growth of new blood vessels, which in turn kicked off bone re-growth and healing.
The researchers said that in the study, bone density surrounding the injury more than doubled to 2.6 cubic millimeters in treated bones compared to 1.2 cubic millimeters in untreated bones.
They found that the new blood vessel growth and bone healing was achieved through a cell pathway that helps the body respond to low oxygen levels, a common problem when blood supply is affected by bone fracture and disease.
Shawn Gilbert, M.D., an assistant professor of orthopedic surgery in the UAB School of Medicine, and Chao Wan, M.D. Ph.D., an instructor in the UAB Department of Pathology, both co-authors on the study, said that the findings on this cell pathway have broad implications for improving treatment of bone fractures, bone disease and other musculoskeletal disorders.
With DF activating this pathway, weve proven a significant point it is possible to explore new, safe and more affordable ways kick-start bone repair. Current treatments use complex proteins, which are expensive to make and cost thousands of dollars per dose. The type of agent used in this study is a simple, small molecule drug that costs hundreds, not thousands, Gilbert said.
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