Drug Rapamycin may be the Way to Treat Kidney Disease

Drug rapamycin may be the answer to treat kidney disease, according to a study at UC Santa Barbara.

Building on past research, the study showed that studies performed on mice are more likely to translate to humans than previously thought.

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Worldwide, around 12 million people are affected from the inherited kidney disease known as autosomal-dominant polycystic kidney disease (ADPKD).

The disease is characterized by the proliferation of cysts that eventually debilitate the kidney, causing kidney failure in half of all patients by the time they reach age 50.

Thomas Weimbs, director of the laboratory where the discovery was made, said that currently, no treatment exists to prevent or slow cyst formation, and most ADPKD patients require kidney transplants or lifelong dialysis for survival, explained.

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The drug rapamycin, also called sirolimus, is currently used as an immunosuppressant, to help prevent rejection of a new, transplanted kidney.

"While we had previously shown that rapamycin is highly effective in mouse models of polycystic kidney disease, the problem had been that these mice had different genes affected than human patients. Therefore, the question always remained whether rapamycin would be effective in patients, too. Our new study now is the first to show that rapamycin is also highly effective in a new mouse model in which the same gene is affected as in most human patients," said Weimbs.

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Currently, there are several clinical trials ongoing internationally to test the safety and efficacy of rapamycin and related drugs in polycystic kidney disease, explained Jonathan Shillingford, first author on the paper.

First results from these studies are expected to appear this year and the scientists hope that these drugs will prove to be beneficial.

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"But it will be critical to balance any benefits against the expected side effects to judge whether these drugs should be recommended for the treatment of polycystic kidney disease," he said.

The Weimbs lab has studied rapamycin in mice for several years.

"To our surprise, treatment of our polycystic kidney mice with rapamycin resulted not only in a halt of further cyst growth but also appeared to partially reverse the already existing kidney deterioration. We had seen this previously in a different mouse model but were very positively surprised that this effect can be replicated in our new model," said Weimbs.

The results are published in the current online issue of the Journal of the American Society of Nephrology.

Source-ANI
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