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Drug Immunity Issues May Find Solutions in Stanford Endeavour

by Savitha C Muppala on  August 19, 2008 at 6:33 PM Drug News   - G J E 4
 Drug Immunity Issues May Find Solutions in Stanford Endeavour
Stanford University researchers seem to have narrowed down upon the amino acid which could support resistant drugs to fight diseases.
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The study authors slated to present their study later this week, will explain in detail the use of arginine in helping drugs outwit pumps in the membrane which have become resistant to the drug.

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In their experiment on mice, scientists employed eight arginine molecules to envelop Taxol, a chemotherapeutic agent, to effectively target the Taxol-immune ovarian cancer cells.

Paul Wender, professor of chemistry at Stanford University, and one of the authors of the study said, "If we think of the pump as being a bouncer for the cellular club, then affectively what we're doing is disguising one of these therapeutic agents to get it in through the back door or side door. We're not even going to deal with the bouncer."

Even though Taxol was employed for the study, researchers were extremely hopeful of arginines' use with other drugs like antibiotics.

"This could potentially be used with any drug which is effective but has a delivery problem," said co-author Nelson Teng, professor of obstetrics and gynecology.



Source: Medindia
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