Drug Donepezil May Reduce Sleep Disturbances In Alzheimer’s Patients
It's long believed that Alzheimer's patients usually experience sleep-disordered breathing and this drug, called donepezil, may reduce these disturbances.
The researchers evaluated the effect of donepezil, on obstructive sleep apnea in 23 patients with Alzheimer disease in a randomized, double-blind design.
For the study, the patients were categorised into two groups: donepezil-treated (11) and placebo-treated (12), and polysomnography and cognitive evaluations were performed at baseline and 3 months.
After the test period, it was found that patients treated with donepezil were found to have improved oxygen saturation, apnea-hypopnea index scores, and cognitive scores, and also increased sleep duration, as compared with those treated with placebo.
This study is published in the recent issue of the journal CHEST.