Drug Companies Urged Not to Give Up Research on Antibiotics

by Gopalan on  September 15, 2008 at 11:31 AM Drug News
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Antibiotics may not bring in oodles of money. But that should not be sufficient reason for drug companies to discontinue research on that class of drugs. For antibiotics remain a critical area for public health, experts stress.

Although new antibiotics have been developed to treat the so-called hospital superbug MRSA (methycillin-resistant Staphylococcus aureus), the pipeline for drugs to treat some other infections was practically dry.

That is doctors are running out of antibiotics to treat infections that could kill vulnerable people.

"It is vital that the pharmaceutical industry remains interested in this area," said Dr David Livermore, laboratory director of UK’s Health Protection Agency's centre for infections.

"Several major companies have pulled out of antibiotic development. They have not been seen as a particularly profitable area. If you develop a new heart drug, the patient is on it for a matter of years and resistance doesn't develop.

"With antibiotics on the other hand, the patient is on it for one or two years and resistance may develop," Livermore points out.

The cost of developing a new drug is usually said to be somewhere between $500m (Ģ285m) and $1bn, depending on whether the many drugs that fail are costed in and whether the marketing budget is included.

Most troubling now is the rise of what are known as gram negative bacteria (MRSA is gram positive). These include E coli, which can cause serious food poisoning, Acinetobacter, which can kill those whose immune system is compromised and Pseudomonas, which particularly attacks cystic fibrosis patients.

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