Down Syndrome Risk in Offspring Increased by Toxic Chemical in Plastic

by Kathy Jones on  September 24, 2011 at 6:07 PM Lifestyle News   - G J E 4
Pregnant women who are exposed to Bisphenol A (BPA) are at a high risk of having a baby with genetic disorders like Down Syndrome, says a new study.
 Down Syndrome Risk in Offspring Increased by Toxic Chemical in Plastic
Down Syndrome Risk in Offspring Increased by Toxic Chemical in Plastic

Researchers at Universitat Autonoma de Barcelona, in collaboration with the Vall d'Hebron Hospital Fetal Tissue Bank, the Department of Gynaecology and the Research Unit of Paediatric Endocrinology, found that BPA can alter the development of oocytes and future ova, possibly diminishing the fertility of a woman's offspring and increasing the risk of Down Syndrome.

The results demonstrated that staying within the safety limits permitted by health authorities does not imply that exposure to the substance is innocuous.

The research, carried out with a culture of 21,570 in vitro oocytes, provides conclusive data for the debate on how BPA affects the health of individuals.

For the first time, human cells were used in a research to analyse the process of cell division of the oocytes - meiosis - in which chromosomes join and exchange material, i.e. meiotic recombination.

Oocytes were cultured for 7, 14 or 21 days in different environments, with the presence of BPA and in control cultures without the substance.

Data obtained in vitro with human cells was practically identical to that obtained with in vivo animal models, while the effects on meiotic recombination, which could lead to the appearance of Down Syndrome, in humans are even greater than those observed in mice.

"According to our results, BPA does not directly affect the fertility of pregnant women, but that of their daughters and granddaughters. It is a multigenerational effect", explains UAB professor Montserrat Garcia Caldes, director of the research.

The research is published in Human Reproduction.

Source: ANI

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

View All

More News on: