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Dog Studies may Help Understand Human Genetic Disorders
In the study with 81 affected dogs and 57 controls from the Nova Scotia duck tolling retriever breed, the researchers identified five loci associated with a canine systemic lupus erythematosus (SLE) -related disease complex. Fine mapping with twice as many dogs validated these loci.
"Our results indicate that the homogeneity of strong genetic risk factors within dog breeds allows multigenic disorders to be mapped with fewer than 100 cases and 100 controls, making dogs an excellent model in which to identify pathways involved in human complex diseases", said Professor Hannes Lohi, University of Helsinki and Folkhalsan Research Center, Finland.
Nova Scotia duck tolling retrievers (NSDTRs) are strongly predisposed to many immune-mediated diseases, including a systemic lupus erythematosus (SLE) -related disease complex comprising an immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA).
The NSDTR breed was developed in the Yarmouth region of Nova Scotia in the early 1800s as a hunting and retrieving dog.
The breed descended from a very small population of dogs that survived two devastating outbreaks of canine distemper virus in 1908 and 1912.
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