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Direct Link Between Insulin, Core Body Temperature Discovered
This is the first time the hormone has been associated with the fundamental process of temperature regulation.
A team led by scientists at The Scripps Research Institute found that when insulin was injected directly into a specific area of the brain in rodents, core body temperature rose, metabolism increased, and brown adipose (fat) tissue was activated to release heat.
The research team also found that these effects were dose-dependent-up to a point, the more insulin, the more these metabolic measures rose.
"Scientists have known for many years that insulin is involved in glucose regulation in tissues outside the brain. The connection to temperature regulation in the brain is new," said Scripps Research neurobiologist Manuel Sanchez-Alavez, who was first author of the new paper with Bartfai lab colleagues Iustin V. Tabarean and Olivia Osborn (now at the University of California, San Diego).
In addition to suggesting a fresh perspective on diseases such as diabetes that involve the disruption of insulin pathways, the study adds to the understanding of core body temperature-the temperature of those parts of the body containing vital organs, namely the trunk and the head.
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