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Dietary Energy Balance Linked to Skin Tumour Development Risk
April 15, 2008 at 3:43 PM
Cancer News
The study suggests that dietary energy balance refers to the balance between caloric intake and energy expenditure.
"We have demonstrated that dietary energy balance directly modulates activation of cell surface receptors, specifically the EGFR and the IGF-1R, which subsequently affects signaling through downstream pathways, such as Akt and mTOR. Negative energy balance inhibits, while positive energy balance enhances, signaling through these pathways, thereby modulating cellular growth, proliferation, and survival," said Tricia Moore, lead author of the study.
According to earlier research, while chronic positive energy balance, which can lead to obesity, increases the risk of developing multiple cancers, a negative energy balance state, as induced by calorie restriction, decreases these risks in most instances.
For the current study, a two-stage skin carcinogenesis model was used to determine the effects of both positive and negative dietary energy balance on skin tumor promotion and progression.
The researchers gave groups of female mice 25 nmol of 7,12-dimethylbenz(a)anthracene (DMBA), a cancer inducing chemical, and then placed them on one of four dietary treatment regimens to generate either a positive or negative energy balance state. After four weeks on their respective diets, the mice received two other cancer inducing chemicals (acetone, 3.4 nmol or 6.8 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA)) twice weekly for the duration of the study.
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More News on: Cysts and Tumours, Pityriasis rosea, Tumor Markers For Cancer Diagnosis and Prognosis, Pemphigus, Hives, Scleroderma, Behcets Syndrome, Pruritus, Vitiligo, Skin Self Examination
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