Fatty acids like omega-6 and omega-3 fatty acids can be new therapeutic targets for diabetes-related tissue injury, a new study by Boston University researchers has revealed.
The team found that these two fatty acids are precursors to a powerful new genus of anti-inflammatory and pro-resolution mediator, also known as 'resolvins' and 'protectins' respectively.
These new local mediators counter and regulate pro-inflammatory signals and return tissues to homeostasis.
In the studies using animal models, the researchers found that these mediators reverse several of the proinflammatory functional responses of white blood cells and macrophages in vitro and prevent inflammation
It exhibits potential for new therapeutic options for resolving inflammation and tissue injury in diabetes.
Vascular changes in diabetes lead to increased risk of myocardial infarction and stroke due to atherosclerosis, retinopathy, end-stage renal disease, debilitating neuropathies, poor wound healing, enhanced risk of infection, and periodontal disease.
The study was presented during the 86th General Session of the International Association for Dental Research.