Medindia

X

Development of Liver Cancer in Hepatitis C Virus Carriers Associated With Genetic Variant

by Kathy Jones on  July 4, 2011 at 9:04 PM Cancer News   - G J E 4
A genetic variant associated with the development of liver cancer in chronic hepatitis C virus carriers has been identified in a genome-wide study by researchers at the RIKEN Center for Genomic Medicine, Hiroshima University Hospital and Sapporo-Kosei General Hospital. The findings are based on a study of 3,312 Japanese individuals and appear in the journal Nature Genetics.
 Development of Liver Cancer in Hepatitis C Virus Carriers Associated With Genetic Variant
Development of Liver Cancer in Hepatitis C Virus Carriers Associated With Genetic Variant
Advertisement

Hepatocellular carcinoma (HCC), the most common type of liver cancer, is the third leading cancer-related cause of death and the seventh most common form of cancer worldwide. The hepatitis C virus (HVC) is the main risk factor for HCC in many western countries and in Japan, where of the more than 30,000 deaths each year from HCC, 70% involve HVC.

Advertisement
To identify risk factors connecting HVC and HCC, the research group conducted a genome-wide study on a group of 3,312 Japanese individuals carrying the hepatitis C virus. Analyzing a total of 467,538 genetic markers (called single nucleotide polymorphisms or SNPs) in a group of 212 HCV carriers with HCC and 765 HCV carriers without HCC, the group uncovered one SNP associated with HCC risk, located on a gene called DEPDC5. The association was confirmed in an independent replication study on a population of 2335 HVC carriers, 710 with HCC and 1625 without HCC.



Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All