"In this study of Chinese patients with type 2 diabetes followed up for 8 years, we found that genetic variants of the PRKCB1 gene were associated with development of incident ESRD independent of other known risk factors, with joint effects among the risk-conferring alleles. These associations persist despite correction for retinopathy, albuminuria [the presence of excessive protein in the urine], renal function, risk factor control, and use of medications including angiotensin-converting enzyme [ACE] inhibitors at baseline," the authors write.
"In addition, we obtained further supporting evidence of the role of genetic variants in the PRKCBl gene in development of chronic kidney disease in an additional cohort of Chinese patients with type 2 diabetes with a comparatively shorter period of follow-up. Our consistent results thus suggest that genetic variation in the PRKCBl gene is an important determinant for the risk of developing DKD in Chinese patients with type 2 diabetes."
Source-Eurekalert