Cell lifespan is limited by telomeres, DNA sequences that cap chromosomes and control the number of times a cell may be copied. A new study reported in Disease Models & Mechanisms (DMM), dmm.biologists.org, describes how telomere dysfunction in skin cells can lead to increased skin cancer risk and pigmentation.
Researchers from Spain investigated the molecular mechanisms underlying skin cell telomere dysfunction using a mouse model of Xeroderma Pigmentosum (XP), a disease in which patients have increased sensitivity to ultraviolet (UV) radiation. Their studies revealed that these mice have impaired skin cell regeneration, and that limiting the activity of a tumor suppressor signaling protein, p53, restores cell regeneration and reduces hyperpigmentation. Surprisingly, limiting p53 activity also advances the progression of skin cancers.
Skin Cancer - Types, Causes, Symptoms, Diagnosis, Treatment & Prevention
Skin cancer is an abnormal growth of skin cells. It can develop due to a continuous exposure to sun over the years.
Skin cancer is an abnormal growth of skin cells. It can develop due to a continuous exposure to sun over the years.
Source-Eurekalert
SRM
Effects of Ultraviolet Radiation
Health concerns of Ultra Violet Radiation in humans need to be clearly understood to protect oneself from prolonged exposures to solar radiation. Section explains effects of UV radiation on human body.
Health concerns of Ultra Violet Radiation in humans need to be clearly understood to protect oneself from prolonged exposures to solar radiation. Section explains effects of UV radiation on human body.
Skin Cancer's Molecular Mechanism Identified
Researchers from University of Minnesota have identified a molecular mechanism that may explain the onset of sun-induced skin cancer.
Researchers from University of Minnesota have identified a molecular mechanism that may explain the onset of sun-induced skin cancer.
