Deadly Liver Cancer Could Be Managed By Altering Body's Metabolism

Researchers have reported that altering the body's metabolism could be an effective treatment for deadly liver cancer.

The finding that inhibiting heat shock transcription factor 1, or HSF1, prevents liver cancer in mice also is another wake-up call that a low-fat, healthy diet is an effective cancer deterrent, said Dr. Demetrius Moskophidis, Cancer Virologist/Immunologist at Georgia Health Sciences University. HSF1 and its target genes are important to metabolism regulation.

Liver Cancer - Types, Causes, Symptoms, Diagnosis, Treatment, Prevention, Progosis
Liver or hepatic cancer is an abnormal growth of cells in the liver. The leading cause of the disease is cirrhosis or scarring of the liver tissue.

"The principle that we demonstrated is that if we change the metabolism, we can interfere with tumour growth," said Moskophidis, co-corresponding author on the study.

GHSU scientists accomplished this by removing HSF1 from the mice; HSF1 inhibitors are under development because of their potential for treating a variety of other cancers such as breast, prostate and kidney cancers.

Removing HSF1 thwarts liver cancer by decreasing access to two critical elements: glucose and lipids or fats.

Zebrafish Model Provides Clues About Deadly Form of Liver Cancer
Using a zebrafish model researchers were able to uncover new information that might help to diagnose and treat hepatocellular carcinoma.

The study is detailed in Cell Metabolism.

Source-ANI

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