Following successful cancer treatment and after receiving an ovarian transplant, a Danish woman has become the world's first to give birth to two babies.
Stinne Holm Bergholdt, from Odense, Denmark, had ovarian tissue removed and frozen during treatment, which was later restored following her recovery.
She then gave birth to a girl in February 2007 after receiving fertility treatment to help her become pregnant. But then, in 2008, she discovered she had conceived a second child naturally and gave birth to another girl in September 2008.
"This is the first time in the world that a woman has had two children from separate pregnancies as a result of transplanting frozen/thawed ovarian tissue," Bergholdt's doctor, Professor Claus Yding Andersen, said.
"These results support cryopreservation of ovarian tissue as a valid method of fertility preservation and should encourage the development of this technique as a clinical procedure for girls and young women facing treatment that could damage their ovaries," he added.
The case has been reported in Europe's leading reproductive medicine journal Human Reproduction.