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DNA Probe Used To View Cancer Gene Activity Outside Body
November 30, 2007 at 2:18 PM
Research News
Researchers at Jefferson Medical College and Jeffersons Kimmel Cancer in Philadelphia said that this technology might someday aid physicians to detect and classify cancer, enabling them to find cancerous breast tumours as early as possible, and determine the appropriate treatment.
Led by Eric Wickstrom, Ph.D., and Mathew Thakur, Ph.D., the research team used a DNA probe a modified nuclear medicine agent to detect the hyperactivity of CCND1, a common breast cancer gene. The gene is copied thousands of times in most breast cancer cells. The high concentration makes CCND1 copies easier to image with the genetic PET probe.
Researchers discovered a much higher concentration of the cancer gene activity in estrogen receptor-positive breast tumours in mice than in normal tissue.
Less than one-fourth of lumps found in mammograms are really cancer. Our new technique will let us see what is really going on in a suspicious lump. We will see if a lump is malignant or something safe, said Dr. Wickstrom, professor of Biochemistry and Molecular Biology at Jefferson Medical College of Thomas Jefferson University.
Dr. Thakur, professor of Radiology and Radiation Oncology at Jefferson Medical College, said: Patients with benign lumps could avoid invasive procedures if active cancer genes could be identified from outside the body. Observing the cancer gene activity of a breast tumor will permit physicians to determine the best way to treat it.
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