The currently available pneumococcal vaccines are effective in preventing invasive pneumococcal disease (IPD), according to a study in the Medical Journal of Australia.
it is likely that, with combined direct and indirect effects, newer conjugate
vaccines could prevent even more IPD than could be prevented with the two
Jeffrey Hanna, a public health physician at the Cairns Public Health Unit of
Queensland Health, and colleagues compared trends in IPD in non-Indigenous
people in north Queensland before and after the introduction of two funded
pneumococcal vaccines in 2005, and examined the proportion of cases that
occurred after the vaccine roll-out that could have been vaccine-preventable.
of the vaccines (7vPCV), protecting against seven pneumococcal serotypes, was
made freely available to children; the other (23vPPV) includes the same seven
serotypes plus an additional 16, and was made freely available to adults aged
65 years or older.
Hanna said that, after the introduction of the vaccines, there were significant
declines for all age groups in the average annual incidence of IPD and a
powerful indirect effect of the 7vPCV in preventing IPD in adults of all ages.
children aged under five, there was a 91 per cent decline in the incidence of
IPD caused by the seven serotypes included in 7vPCV; in adults, there was a 62
per cent decline in IPD due to the same seven serotypes for those aged 15-64,
and a 77 per cent decline for those aged 65 and over.
marked decline (34 per cent) in overall IPD incidence in 2006-2009 can be
attributed to pneumococcal vaccination," Dr Hanna said.
impressive was the 77 per cent decline across all ages of IPD caused by 7vPCV
the study also found that IPD serotype 19A, which is not included in 7vPCV, has
emerged as a dominant serotype in the region.
surveillance will be essential to monitor further trends in IPD in north
Queensland and elsewhere."
Journal of Australia
is a publication of the Australian Medical