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Curative Properties of Red Wine Against Heart Disease is Set to Be Tested
SRT501, a version of resveratrolis will also be tested in India for diabetes and several versions of the drug.
The new drugs are a result of and earlier research that found that longevity can be increased through a calorie-restricted diet.
The study found that reducing calories by 40 per cent prolongs lifespan by 50 per cent or more – in yeast, mice, rats and every other species so far tested.
In 1999 David Sinclair, at Harvard, showed that a single gene, SIRT1, controlled ageing process.
More work revealed that resveratrol activates the gene, explaining why red wine is good for health.
Dr Sinclair, who is now a director of Sirtris Pharmaceuticals, based in Cambridge, Massachusetts, with Joseph Baur and others, showed that in mice the adverse effects of a high-calorie diet could be reversed by resveratrol.
Sitris has developed a more powerful version of resveratrol, SRT501¸to that can be effective for treating degenerative disease, diabetes.
In mice and rats, SRT501 cuts weight gain in animals fed on calorie-rich diet. When combined with Met-formin, a diabetes drug, it makes mice run faster than their other mates.
This happens by increasing the production of mitochondria, which are tiny powerhouses that increase muscle power.
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