Medindia

X

Crack in Stomach Ulcer Bacteria Could Lead to New Antibiotics

by VR Sreeraman on  October 3, 2009 at 1:36 PM Research News   - G J E 4
 Crack in Stomach Ulcer Bacteria Could Lead to New Antibiotics
Scientists claim to have identified a crack in the armor of a common microbe that causes stomach ulcers and other diseases.
Advertisement

They have identified a group of substances that block a key chemical pathway that the bacteria need for survival, which could lead to more effective antibiotics to fight these hard-to-treat microbes

Advertisement
Lead researcher Javier Sancho revealed that Helicobacter pylori (H. pylori) bacteria infect the stomach lining and can cause gastritis and ulcers. Treatment with broad-spectrum antibiotics can cure H. pylori infections.

Scientists were already aware that blocking flavodoxin, a key protein that H. pylori needs for survival, could be the key to developing narrow-spectrum antibiotics that specifically target H. pylori.

In the new study, Sancho's team screened 10,000 chemicals for their ability to block flavodoxin and identified four that showed promise.

They then showed that three of the four substances killed H. pylori in cell cultures and did not have any apparent toxic effects in lab animals.

"These new inhibitors constitute promising candidates to develop new specific antibiotics against H. pylori," said the study.

The study will appear in ACS Chemical Biology, a monthly journal.

Source: ANI
SRM
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All