Scientists from Missouri University of Science and Technology have developed a cottony glass material which may help diabetics
suffering from hard-to-heal open wounds.
The glass fiber material could become a source of relief for
diabetics fighting infections. It also could be used by battlefield medics or
emergency medical technicians to treat wounds in the field.
In a recent clinical trial, the material was found to speed
the healing of venous stasis wounds in eight out of the 12 patients enrolled in
the trial. Details about the trials and the material were published in the May
2011 issue of the American Ceramic Society's Bulletin magazine.
The material - a nanofiber borate glass - was developed in
the laboratories of Missouri S&T's Graduate Center
for Materials Research and the Center for Bone and Tissue Repair and
Regeneration, says Dr. Delbert E. Day, Curators' Professor emeritus of ceramic
engineering and a pioneer in the development of bioglass materials. Day and his
former student, Dr. Steve Jung, developed the material over the past five
Other bioactive glass materials are formed from silica-based
glass compositions and have been used primarily for hard-tissue regeneration,
such as bone repair. But Day and Jung experimented with borate glass, which
early lab studies showed reacted to fluids much faster than silicate glasses.
"The borate glasses react with the body fluids very quickly"
when applied to an open wound, says Day. "They begin to dissolve and release
elements into the body that stimulate the body to generate new blood vessels.
This improves the blood supply to the wound, allowing the body's normal healing
processes to take over."
Clinical trials at Phelps County
Center in Rolla began in
the fall of 2010 with 13 subjects. One dropped out early in the process. All
suffer from diabetes and had wounds that had been unhealed for more than a
Depending on the severity of the wound, Day says the wounds
can heal within a few weeks to several months after the material is applied.
"Within a few days, most patients see an improvement," he says.
The material is produced at Mo-Sci Corp., a glass technology
company founded by Day. Jung is a glass scientist at the company and holds
bachelor's and master's degrees in ceramic engineering and a Ph.D. in materials
engineering from Missouri S&T.
"Rolla is extremely fortunate to have the three key
ingredients needed to take research from the idea stage to the commercial
product stage," says Day, who also invented TheraSphere, a glass product now
used to treat patients with liver cancer at more than 100 sites worldwide,
including Barnes Jewish Hospital in St.
Louis. "We have the university, which provides the
research expertise, Phelps
for the clinical trials, and Mo-Sci for the manufacturing and
Day foresees expanding the clinical trials to include
patients with other types of wounds, such as burn victims.