Higher doses of statin may not always work to prevent diseases of the coronary artery, a new study has claimed.
Statins have been found to be highly efficient in lowering cholesterol. Usually, a treat-to-target approach, which means treating to a target cholesterol level, is taken with statin therapy.
But according to some experts, a tailored approach using different dosages based on patients' risk for cardiovascular disease could work better for reducing the risk of coronary artery disease.
Researchers created a computer simulation to compare two treatment approaches at the population level-- giving fixed doses of statins depending on a person's five-year coronary artery disease risk (tailored treatment), or increasing statin doses to attain particular lipid level targets (treat-to-target).
It was seen that the tailored fixed-dose strategy saved more quality-adjusted life-years and treated fewer persons with high-dose statin therapy as compared to the intensive treat-to-target approach.
Researchers say that tying statin treatment individual risk for heart disease and potential benefits may be better than methods that concentrate on realizing certain lipid level targets.
The study will appear in Annals of Internal Medicine.